Most people do not experience ANY side effects as a result of the medication. However, as with any medicine that you introduce to your body, a small percentage of people might experience minor digestive issues or mild headaches initially and for a short amount of time. Truvada can lead to slight changes in bone density or kidney function but rarely do these changes cause serious medical issues. Descovy is less likely to cause medical issues. Both medications have been proven very safe and effective. Your provider will closely monitor your overall health to ensure that no issues occur.